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KMID : 1002120090060010035
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Journal of Korean Sleep Research Society
2009 Volume.6 No. 1 p.35 ~ p.41
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Mechanisms of obstructive sleep apnea development
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Yoon Dae-Wui
Shin Chol
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Abstract
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Although obstructive sleep apnea (OSA) is a major public health problem, the pathogenesis of OSA is not fully understood. According to recent studies, development of OSA generally depends on the followings : (1) upper airway anatomy, (2) the ability of upper airway dilator muscle to respond to stimulation, (3) loop gain, (4) arousal threshold. These factors determine upper airway patency and ventilatory control stability. Thus, abnormalities in these systems lead to a narrowed, more collapsible pharyngeal airway and ventilator control instability, which lead in turn to development of OSA. OSA is a heterogeneous disorder which can develop as the result of a variety of physiologic characteristics, and may differently respond to therapeutic approaches based on the predominant abnormality. Therefore, the treatment of OSA must be individualized to the cause of the development of OSA.
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KEYWORD
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Obstructive sleep apnea, Upper airway, Loop gain, Arousal threshold, Ventilatory control stability
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